Quilmes National University

Currently, the enterocyte cell line Caco-2 is a well-established model for the human intestinal barrier. However, these cultures do not completely recapitulate the three-dimensional (3D) organization of cells and extracellular matrix within tissues and organs. One of the most important features is the lack of interaction with immune-competent cells, which is very important not only for uptake and for processing of nanoparticles, but also for modelling inflammatory disorders.

In this project we develop an intestinal ephitelial model that include immune cells, and then we induce inflammation to test the toxicity and efectivity of nanoparticles.