Quilmes National University

Non-communicable diseases (NCDs) are responsible for 3.9 million deaths each year in the Region of the Americas, representing ¾ of all deaths. An estimated 200 million people in the Americas are living with NCDs, which has a tremendous impact on their life, well-being, and ability to work. This, in turn, poses major challenges to the economy, the health system, and other sectors of society. Four main NCDs are responsible for the greatest burden: cardiovascular disease, diabetes, cancer, and chronic respiratory diseases. These diseases, if not detected early and managed properly, can cause severe complications that threaten an individual’s health, ability to work, and overall well-being, posing significant burdens to families, communities, and countries

(http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&gid=16221&Itemid=270). Atherosclerosis is the main cause of heart attack and stroke, the two most deadly NCD in the planet. Atherosclerosis is a chronic inflammatory disease of the arterial wall resulting from a dysregulation of the lipid metabolism and a pathological inflammatory response.

Long circulating archaeosomes (LCA) exhibiting a special surface modified with cholesterol, cholesteryl-hemisuccinate or DSPE-PEG2000 combine improved targeting to foam cells with high intracellular delivery of bisphosphonates and anti-inflammatory agents.

Loaded with MRI contrast agents, drug loaded LCA are currently being explored as selective theranostic agents to label and destroy foam cells in the vulnerable plaque.