Quilmes National University

Consisting of an epithelial cell layer complimented with human blood monocyte derived macrophages and dendritic cells on the apical and basolateral sides respectively), cultured on a micro-porous membrane insert, is being developed according to [Rothen-Rutishauser, B. M., Kiama, S. G. & Gehr, P. A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am. J. Respir. Cell Mol. Biol. 32, 281–289 (2005)], [Blank, F., Rothen-Rutishauser, B. & Gehr, P. Dendritic cells and macrophages form a transepithelial network against foreign particulate antigens. Am. J. Respir. Cell Mol. Biol. 36, 669–677 (2007)], [Rothen-Rutishauser, B., Blank, F., Muhlfeld, C. & Gehr, P. In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter. Exp. Opin. Drug Metab. Tox. 4, 1075–1089 (2008)]